Incidence & Distribution of Sanfilippo Syndrome

MPS III is the most common type of Mucopolysaccharidosis; the estimated incidence of all four subtypes combined is 1 in 70,000 newborns.

By Type of Sanfilippo

Type Incidence in Thousands# Prevalence in Thousands* Carrier Frequency
Type A 128 114 169
Type B 235 211 230
Type C 1407 1407 593
Type D 1056 1056 514
Source: Meikle PJ, Hopwood JJ, Clague AE, Carey WF (January 1999). “Prevalence of lysosomal storage disorders”. JAMA. 281 (3): 249–54. doi:10.1001/jama.281.3.249. PMID 9918480.

Factors in Sanfilippo

Sanfilippo Syndrome appears to affect every gender, nationality, socio-economic bracket, and geographic region.

Co-occurring Conditions

Children with Sanfilippo Syndrome are also often diagnosed with Autism.

Additional Information